With the loss Ole Miss fell to 8-13 (1-7 SEC) while Arkansas improved to 15-6 (3-5 SEC).
Diara Moore scored in double figures for the team-leading 15th time this year with 14 points while Tia Faleru also added 14 points. Valencia McFarland added 11 points and added a team-high eight rebounds.
The Razorbacks went on a 20-3 run capped at the 3:36 mark to pull away from the Rebels.
Ole Miss used three early three pointers, two from Moore and one from Faleru, to build a 15-7 lead with 13:12 remaining in the first half.
Arkansas tied the game at 25-25 with 6:45 left in the half. The Razorbacks took their first lead of the game since the team led, 3-0, with 3:39 remaining in the half as Arkansas went up 34-33 lead.
At the half, Arkansas led, 38-35. Moore led the Rebels with 12 points while Faleru added seven. As a team, Ole Miss shot 28.1 percent (9-32) from the floor while Arkansas shot 44.1 percent (15-34). The Rebels were 13-14 from the free throw line in the first half.
In the second half, the Razorbacks led by six, 44-38, with 16:34 left in the half before Ole Miss went up one, 45-44, on a three from Faleru.
Ole Miss will play at Vanderbilt Sunday at 2 p.m.