Williams started in place of injured center Isabelle Harrison, who will undergo surgery Friday on her left knee. The senior guard had six assists and six steals to go along with her double-double.
Meighan Simmons scored 21 points, Taber Spani added 15 points and Bashaara Graves had 10 points as the Lady Vols (17-4, 8-0 SEC) led from start to finish. Martha Alwal had 16 points and nine rebounds for Mississippi State (9-12, 1-7), which has never beaten Tennessee in 34 attempts.
Tennessee forward Cierra Burdick returned to action Thursday after missing eight games with a broken right hand. Burdick, normally a starter, had four points and five rebounds off the bench.