Marquette (3-1) never trailed, and the Bulldogs never trailed by less than 10 points after the opening minutes.
Gardner finished with 15 points and 12 rebounds.
Mississippi State didn’t score in the first four minutes as Marquette built an 8-0 lead. Gavin Ware hit a jumper and Craig Sword had a steal and dunk to make it 8-4, but Marquette responded by scoring 10 straight points in less than two minutes.
Mississippi State (1-3) had 22 turnovers — 15 in the first half. Fred Thomas had 17 points for the Bulldogs.