Chief Deputy Greg Wright says one man was fatally shot in the chest.
Macon police said they were tipped-off about drugs being at George's Washington Street home.
Deputies originally tried to pull him over for possibly driving under the influence.
Joshua Reed, 21, of Starkville, and Kody McNair, 20, of Hattiesburg, have been charged with armed robbery.
The case remains under investigation.
Pope remains in the Lowndes County jail.
Jeremiah Antonio Payne, 20, has an outstanding warrant.
Sheriff Eddie Scott said his officers found three starving horses at Cumming's property last week.
The suspect confronted the store employee around after the Highway 45 North location closed.
Investigators said the woman was unable to move around the home or even go to the restroom.